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Prevention of secondary complications: Aggressive education on the management of fevers; prophylactic antibiotics, including penicillin in children; up-to-date immunizations; folic acid supplementation; and iron chelation therapy for those with iron overload.

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Within pediatric patients with SCD, VAS and NRS ratings were found to trend together; however, VAS scores were found to be significantly lower than NRS scores across assessments.

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Although hematologic changes indicative of SCD are evident as early as the age of 10 weeks, symptoms usually do not develop until the age of 6-12 months because of high levels of circulating fetal hemoglobin.

The majority of patients with CML are diagnosed because they have a high white blood cell count, but on occasion patients with CML will only have a high platelet count, therefore every patient with suspected ET is also evaluated for CML, with a test for the Philadelphia chromosome.

It inhibits the production of the hemoglobin S that causes sickle cell anemia and favors the reactivation of fetal hemoglobin (HbF) expression.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

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Hydroxyurea had previously been used as a agent, and there is some concern that long-term use may be harmful, but this risk has been shown to be either absent or very small and it is likely that the benefits outweigh the risks.

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